🔬 Developing novel therapeutics to treat Alzheimer's Disease
🧬 Targeting the Amylin Receptor — a breakthrough approach in AD research
💊 Advancing both Peptide & Small Molecule drug candidates
🏫 Founded from pioneering research at the University of Alberta
🧪 Screened over 7 million compounds to identify Alzheimer's blockers
🐭 Proven efficacy in Alzheimer's mouse models — improved memory & learning
🤝 Collaborating with world-leading scientists & academic institutions
🌍 Developing disease-modifying therapies for early & late-stage Alzheimer's
🏆 Led by award-winning neurologist Dr. Jack Jhamandas (30+ yrs expertise)
🔭 Using Cryo-EM to understand drug-receptor binding mechanisms
🔬 Developing novel therapeutics to treat Alzheimer's Disease
🧬 Targeting the Amylin Receptor — a breakthrough approach in AD research
💊 Advancing both Peptide & Small Molecule drug candidates
🏫 Founded from pioneering research at the University of Alberta
🧪 Screened over 7 million compounds to identify Alzheimer's blockers
🐭 Proven efficacy in Alzheimer's mouse models — improved memory & learning
🤝 Collaborating with world-leading scientists & academic institutions
🌍 Developing disease-modifying therapies for early & late-stage Alzheimer's
🏆 Led by award-winning neurologist Dr. Jack Jhamandas (30+ yrs expertise)
🔭 Using Cryo-EM to understand drug-receptor binding mechanisms
Resources

Peer-reviewed research. from our team..

Egeiro’s scientific foundation is built on over a decade of published discovery in Alzheimer’s neuroscience.

Selected Research Papers

2022

Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro
Soudy R., Kimura R., Fu W., Patel A., Jhamandas J. PLoS One, April 2022; 17

2021

Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer’s Disease Mouse Models.
Patel A, Kimura R, Fu W, Soudy R, MacTavish D, Westaway D, Yang J, Davey R, Zajac J, Jhamandas, JH MOLECULAR NEUROBIOLOGY. 2021 July; 58

2020

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Cunnane S.C., Trushina E., Morland C., Prigione A., Casadesus G., Andrews Z.B., Beal M.F., Bergersen L.H., Brinton R.D., de la Monte S., Eckert A., Harvey J., Jeggo R., Jhamandas J.H., Kann O., la Cour C.M., Martin W.F., Mithieux G., Moreira P.I., Murphy M.P., Nave K.A., Nuriel T., Oliet S.H.R., Saudou F., Mattson M.P., Swerdlow R.H., Millan M.J. Nature Reviews Drug Discovery. 2020 September; 19 (9):609-633

2019

Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.
Soudy R, Kimura R, Patel A, Fu W, Kaur K, Westaway D, Yang J, Jhamandas J.
Scientific Reports, July 2019; 9(1):10942

2017

Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation
Kimura R, MacTavish D, Yang J, Westaway D, Jhamandas JH.
Molecular Neurobiology, January 2017; 54(1):748–754

2017

Amylin Receptor: A Potential Therapeutic Target for Alzheimer's Disease.
Fu W, Patel A, Kimura R, Soudy R, Jhamandas JH.
Trends in Molecular Medicine, August 2017; 23(8):709–720

2013

Role of amylin and its receptors in neurodegeneration.
Fu W, Jhamandas JH.
Current Protein & Peptide Science, June 2013; 14(4):338–45

2012

Neuronal receptors as targets for the action of amyloid-beta protein (Aß) in the brain
Patel AN, Jhamandas JH.
Expert Reviews in Molecular Medicine, January 2012; 14:e2
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